Università di Milano
ITALY
Bifunctional dyes for base metal-catalysed C-C and C-X cross-couplings promoted by visible light
Chemistry
Organic synthesis / homogeneous catalysis
Master Degree or equivalent in Chemistry / Industrial Chemistry
(1) C-heteroatom methodologies promoted by Fe, Co, Ni, Cu in the presence of bifunctional organic photoredox catalysts under visible light irradiation.
(2) C-C cross-coupling methodologies promoted by Fe, Co, Ni, Cu in the presence of bifunctional organic photoredox catalysts under visible light irradiation.
(3) Application of the new methodologies to industrially relevant targets.
JANSSEN (3 months): training on high-throughput experimentation/possible validation with industrial targets.
LIKAT (7 months): application of catalysts/methodologies to deoxygenative cross-coupling / Study of heterogeneous catalyst systems.
University of Graz
AUSTRIA
Base-metal nanoparticle catalysts for C-C or C-N coupling reactions in alternative reaction media with integrated product separation
Chemistry
Organic synthesis / homogeneous catalysis
Master Degree or equivalent in Chemistry / Industrial Chemistry
(1) C-C and C-N cross-coupling methodologies involving aromatic substrates with –OCH3 functionalities, using monometallic and bimetallic NPs based on Fe, Ni, Co, Mn or Cu in natural ionic liquids (ILs) or deep eutectic solvents.
(2) Demonstrating catalyst recyclability and integrated product separation using appropriate biphasic systems.
(3) Application of the methods on lignin-derived product streams.
JANSSEN (3 months): training on high-throughput experimentation / possible validation with industrial targets.
FIS (7 months): scale-up of the most successful methodologies / possible validation with industrially relevant compounds.
University of Caen
FRANCE
Cross-coupling by C-H functionalization reactions promoted by HetCpCo(III) and HetCpFe(II) complexes
Chemistry
Organic synthesis / homogeneous catalysis
Master Degree or equivalent in Chemistry / Industrial Chemistry
(1) Synthesis of HetCpCo(III) and HetCpFe(II) complexes.
(2) Use of the HetCpCo(III) in cross-couplings involving C(sp2)-H and C(sp3)-H activation (O-acyl oxime annulation | amidation).
(3) Use of the HetCpFe(II) in cross-couplings involving C-H activation (1,2-alkene deamination | cyclopropanation | visible light-induced C-H functionalisation).
(4) Application of the new methodologies to industrially relevant targets.
JANSSEN (3 months): training on high-throughput experimentation / possible validation with industrial targets.
FIS (7 months): application of the new catalysts to Kumanda-type coupling / scale-up of the most successful methodologies/possible validation with industrially relevant compounds.
Leibniz Institute Catalysis
GERMANY
C-C bond formation by deoxygenative cross-coupling of carbonyl compounds promoted by homogeneous and heterogeneous base metal-catalysts
Chemistry
Organic synthesis / homogeneous catalysis / heterogeneous catalysis
Master Degree or equivalent in Chemistry / Industrial Chemistry
(1) Synthesis of homogeneous Fe- and Mn-catalysts.
(2) Synthesis of heterogeneous Mn-, Fe-, Co-, Ni-, Cu-catalysts.
(3) base metal-catalytic methodologies for deoxygenative cross-coupling of ketones / aldehydes in the presence of hydrazine.
(4) Application of the new methodologies to industrially relevant targets.
JANSSEN (3 months): training on high-throughput experimentation / possible validation with industrial targets.
FIS (7 months): scale-up of the most successful methodologies/possible validation with industrially relevant compounds.
Fabbrica Italiana Sistetici
ITALY
Sustainable Fe-catalysed Kumada-type cross-couplings for the synthesis of APIs
Chemistry
Organic synthesis / homogeneous catalysis
Master Degree or equivalent in Chemistry / Industrial Chemistry
(1) Investigation and screening of homo- and heterogeneous Fe-catalysts in cross-couplings.
(2) Development of novel Fe-catalysed cross-coupling reactions for sustainable C-C bond formation.
(3) Application of the new methodologies to industrially relevant targets, with a particular focus on bipyridine scaffolds.
(4) Selected transformations submitted to the process development.
UNI GRAZ (7 months): application of catalyst/methodologies developed at UNI GRAZ to Kumanda-type cross-couplings.
Janssen Pharmaceutica NV
BELGIUM
Base metal catalysts for cross-couplings relevant to the pharmaceutical industry
Chemistry
Organic synthesis / homogeneous catalysis
Master Degree or equivalent in Chemistry / Industrial Chemistry
(1) Extensive exploration of the chemical spaces (at least 5000 experiments/year via HTE) resulting in at least 2 leads/year.
(2) At least one lead being optimized in a catalyst suited for large scale production.
(3) Scale-up, of the synthesis of at least one target API and/or API intermediate.
UMIL (2.5 months): photoredox catalytic approaches to C-C and C-B coupling.
UNICAEN (2.5 months): test of HetCpCo(III) and HetCpFe(II) complexes in C-C and C-B coupling.
LIKAT (2.5 months): study of heterogeneous catalytic approaches to C-C and C-B coupling.
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This project has received funding from the European Union’s research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101119574
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