Catalysis is today exploited for preparing ca. 90% of chemical and pharmaceutical products. Use of catalysts allows for efficient chemical transformations, limiting the energy consumption and improving selectivity and atom economy. However, a large number of catalytic systems rely on noble metals (e.g., Pd, Pt, Rh, Ir, Au), with associated sustainability issues. Indeed, all these metals are undergoing strong price fluctuations and will face supply limitations in the future. Moreover, given the toxicity of most precious metals, the tolerated threshold in fine chemicals and APIs is very low, with associated purification costs (solvents, energy, generation of waste). For these reasons, replacement of noble metals with the cheaper “base metals”– in particular, 1st row transition metals such as Mn, Fe, Co, Ni, Cu – is becoming a compelling goal for chemists, as well as a need for society. However, this goal also represents a tremendous challenge, as the typical reactivity of 2nd and 3rd row TMs cannot be easily transferred to 1st row TMs, due to their different electronic structure: the so-called “base metals” tend to form high spin complexes and to engage in single electron transfer rather than in the multielectron redox steps typical of noble metals.
NextBase is an intersectoral consortium of research groups with a strong expertise in catalysis, who will join forces to take the challenge of noble metal replacement in cross-coupling reactions – a class of transformations of high industrial importance for producing fine chemicals and APIs. Synergies and complementary types of expertise within the DN will be exploited (i) to harness the reactivity of 1st row TM for several types of cross-coupling, which will be also applied to industrially relevant targets, and (ii) to train PhD students aware of the importance of sustainability issues and expert in the use and combination of sustainable catalytic methodologies.
DC projects
01
UMIL
Bifunctional dyes for base metal-catalysed C-C and C-X cross-couplings promoted by visible light
02
UNI GRAZ
Base-metal nanoparticle catalysts for C-C or C-N coupling reactions in alternative reaction media with integrated product separation
03
UNICAEN
Cross-coupling by C-H functionalization reactions promoted by HetCpCo(III) and HetCpFe(II) complexes
04
LIKAT
C-C bond formation by deoxygenative cross-coupling of carbonyl compounds promoted by homogeneous and heterogeneous base metal-catalysts
05
FIS
Sustainable Fe-catalysed Kumada-type cross-couplings for the synthesis of APIs
06
JANSSEN
Base metal catalysts for cross-couplings relevant to the pharmaceutical industry
There are strict eligibility requirements for the DC positions in MSCA DNs. Please ensure to be qualified before applying, as ineligible candidates cannot be considered.